Synthetic derivatives of aromatic abietane diterpenoids and their biological activities.

نویسنده

  • Miguel A González
چکیده

Naturally occurring aromatic abietane diterpenoids (dehydroabietanes) exhibit a wide range of biological activities. A number of synthetic studies aimed at modifying the abietane skeleton in order to obtain new potential chemotherapeutic agents have been reported. In this study, the biological activities of synthetic derivatives of aromatic abietane diterpenoids are reviewed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Aromatic abietane diterpenoids: their biological activity and synthesis.

In this study, the biological properties of natural abietane-type diterpenoids with an aromatic C ring are reviewed. An overview of the synthetic studies of this group of abietanes, including dehydroabietic acid, callitrisic acid and ferruginol, is presented. The review contains about 160 references.

متن کامل

Abietane acids: sources, biological activities, and therapeutic uses.

The biological activities of natural abietane acids and their derivatives have been reviewed from 1967 to 1992. Antimicrobial, antiulcer, and cardiovascular activities are the most representative for this class of diterpenoids, while others like allergenic, antiallergic, filmogenic, surfactant, antifeedant, etc. activities, which determine several uses of abietane acids, have also been reported.

متن کامل

Biological Activity of Diterpenoids Isolated from Anatolian Lamiaceae Plants

In this study, antibacterial, antifungal, antimycobacterial, cytotoxic, antitumor, cardiovascular, antifeedant, insecticidal, antileishmanial and some other single activities of diterpenoids and norditerpenoids isolated from Turkish Lamiaceae plants, are reviewed. The diterpenoids were isolated from species of Salvia, Sideritis, and Ballota species growing in Anatolia. Fifty abietanes, ten kaur...

متن کامل

Antimicrobial abietane diterpenoids against resistant bacteria and biofilms

Antimicrobial resistance (AMR) is a growing worldwide threat to public health due to the increase of resistant pathogens to the existing antimicrobial therapy. Common and nosocomial infections are beginning to require 2nd and 3rd line antibiotic therapy, increasing time and cost of treatment, and also contributing to the development of multidrug resistance (MDR). Natural products remain an impo...

متن کامل

Pharmacological Profile of Oxazine and its Derivatives: A Mini Review

Oxazine derivatives are significant class of heterocycle compounds, which has involved much synthetic attention due to their extensive variety of pharmacological activities. Oxazine is a heterocyclic compound can be formally derived from benzene, and its reduction products, by suitable substitution of carbon (and hydrogen) atoms by nitrogen and oxygen. In the last few years oxazine derivatives ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • European journal of medicinal chemistry

دوره 87  شماره 

صفحات  -

تاریخ انتشار 2014